For Contract Research Organizations
Run a Blinded Benchmark on Your Own Compounds
We don't ask you to trust our published validation. Test ChiralCall against your own ground truth first.
Submit up to 150 chiral compounds where you already know the eutomer. Get ChiralCall's predictions back. Compare them against your ground truth using our browser-based report — your answers never leave your machine. Free for 60 days. No credit card. No commitment.
How the Blinded Benchmark Works
Pick your test set
Choose 20–150 chiral compounds where you already know the active enantiomer. Internal compounds from recent programs work best. Include compounds from each compound class you care about. NDA available before you submit proprietary structures.
Submit via batch API
Send your SMILES as a JSON array to /api/v1/batch. Each result includes the predicted eutomer, a calibrated confidence score, compound class match, and per-class accuracy with Wilson confidence intervals. All processing is stateless — your SMILES are never stored.
Compare with your ground truth
Open the Comparison Report page. Paste ChiralCall's predictions and your known answers. The report runs entirely in your browser — your ground truth never leaves your machine and is never sent to our servers.
Decide with data
The report shows overall accuracy, per-class breakdown, false-confident misses, and out-of-scope calls — all computed on your chemical matter. Share internally to make an informed go/no-go decision.
Sample Batch API Output
Here's what you'll see for each compound. This example shows three well-known drugs submitted via the batch API.
{
"results": [
{
"smiles": "CC(C)Cc1ccc(cc1)[C@@H](C)C(=O)O",
"prediction": "(S)-enantiomer",
"direction": "S",
"confidence": 92,
"matchType": "scaffold",
"drugClass": "Arylpropionic acid (profen NSAID)",
"drug_class_stats": {
"n_validated": 44,
"accuracy_pct": 100.0,
"wilson_ci_lower": 92.0,
"wilson_ci_upper": 100.0,
"tier": "T1"
}
},
{
"smiles": "OC(=O)CC(CC(=O)O)(O)C(=O)O",
"prediction": "out_of_scope",
"matchType": "none",
"drugClass": null,
"note": "No matching compound class found"
},
{
"smiles": "CC(=O)Oc1ccccc1C(=O)O",
"prediction": "achiral",
"matchType": "none",
"drugClass": null,
"note": "No stereocenters detected"
}
],
"summary": { "total": 3, "predicted": 1, "out_of_scope": 1, "achiral": 1 }
}Predicted
Ibuprofen — correctly identified as an arylpropionic acid with (S)-eutomer. Confidence 92, backed by 44 validated compounds at 100% class accuracy.
Out of scope
Citric acid — no matching compound class. ChiralCall returns “out of scope” rather than a low-confidence guess.
Achiral
Aspirin — no stereocenters detected. Handled gracefully without wasting a prediction.
What the Pilot Includes
150 predictions over 60 days
Single or batch, via web UI or API
Batch API access
Submit up to 50 compounds per request, 5 batches per hour
API key generation
Create and manage API keys from your dashboard
Per-compound confidence scores
Calibrated 0–100 probability of correctness
Per-class Wilson CIs and LOO accuracy
Statistical evidence backing each prediction
Browser-based comparison report
Your ground truth never leaves your machine
Stateless processing
SMILES processed in memory only. Nothing stored.
Auto-converts to Free tier
After 60 days or 150 predictions, whichever comes first
Pilot Scoring Template
Track your benchmark in a spreadsheet with auto-calculated summary metrics.
Download XLSX templateClient IP Protection
We understand that CROs handle confidential client structures. ChiralCall is designed for this:
Check coverage before you commit
Paste any SMILES into our free scope checker to see instantly whether ChiralCall covers your compound class — no account, no API key, no data stored.
What ChiralCall does and does not do
ChiralCall predicts the historically favored eutomer direction within validated compound classes, for first-pass synthesis and assay prioritization. It does not replace experimental confirmation.
Compounds outside our compound classes receive an “out of scope” response rather than a forced prediction. We believe this is more useful than low-confidence guesses.
Current coverage spans pharmaceuticals and agrochemicals. Before signing up, you can check if your compounds are in scope — free, no account required. Or see the full list in the compound class browser.
After the Benchmark
If ChiralCall performs well on your compounds, the Founding Customer plan provides unlimited API access at $9,995/year — a rate locked for the lifetime of your account. For organizations processing hundreds of compounds per month, this is typically less than the cost of a single chiral resolution.
Enterprise options (custom SLA, dedicated support, higher rate limits) are available.
Academic institutions with .edu email addresses get unlimited predictions free, permanently.
ChiralCall predicts the historically favored eutomer within validated compound classes. It is a chirality decision layer for first-pass chiral prioritization — not a replacement for experimental confirmation. Predictions are provided for research use.